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Childhood exercise may protect against memory loss in old age

By Andy Coghlan

14 August 2017

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Can exercise during childhood protect you against memory loss many decades later? Exercise early in life seems to have lifelong benefits for the brain, in rats at least.

鈥淭his is an animal study, but it indicates that physical activity at a young age is very important 鈥 not just for development, but for the whole lifelong trajectory of cognitive development during ageing,鈥 says of the University of Toronto, Canada. 鈥淚n humans, it may compensate for and delay the appearance of 础濒锄丑别颈尘别谤鈥檚 symptoms, possibly to the point of preventing them.鈥

When will we cure Alzheimer’s?

Wojtowicz鈥檚 team spilt 80 young male rats into two equal groups, and placed running wheels in the cages of one group for a period of six weeks. Around four months later 鈥 when the rats had reached middle age聽鈥 the team taught all the rats to associate an electric shock with being in a specific box. When placed in the box, they froze with fear.

Two weeks later, the team tested the rats in three scenarios: exactly the same box in the same room, the same box with the room arranged and lit differently, and a completely different box in a different room.

The rats without access to a running wheel when they were young now froze the same proportion of times in each of these situations, suggesting they couldn鈥檛 remember which one was hazardous. But those that had been able to run in their youth froze 40 to 50 per cent less in both altered box settings.

鈥淭he results suggest the amount of physical activity when we鈥檙e young, at least for rodents, has implications for brain and cognitive health鈥攊n the form of better memories鈥攚hen we鈥檙e older,鈥 says of Northeastern University in Boston, who has found that, in humans, exercise stimulates the growth of new brain cells.

eNeuro DOI: 10.1523/ENEURO.0237-17.2017

This article will appear in print under the headline “Young runners remember better when old”

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